Inflammation can limit the effectiveness of local anesthetics

The increased acidity associated with the inflammatory process, common to every surgical procedure, can make it more difficult for local anesthetics to prevent pain. Two endodontists, Hargreaves and Keiser, examine acidosis as a result of inflammation in the following in-depth review, discussing local anesthetics’ mechanisms of action, why they are limited, and how to manage pain in light of these facts.

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